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Potassium Carbonate → 4-[((2S)-2-Amino-3-{7-[2-(1H-pyrrol-1-yl)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)oxy]benzonitrile

HRID 1374119
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HRID 1374119 반응식
[C:1]([C:3]1[CH:29]=[CH:28][C:6]([O:7][CH2:8][C@@H:9]([NH:20]C(=O)OC(C)(C)C)[CH2:10][N:11]2[CH2:18][CH:17]3[O:19][CH:13]([CH2:14][NH:15][CH2:16]3)[CH2:12]2)=[CH:5][CH:4]=1)#[N:2].Br[CH2:31][CH2:32][N:33]1[CH:37]=[CH:36][CH:35]=[CH:34]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[NH2:20][C@@H:9]([CH2:10][N:11]1[CH2:18][CH:17]2[O:19][CH:13]([CH2:14][N:15]([CH2:31][CH2:32][N:33]3[CH:37]=[CH:36][CH:35]=[CH:34]3)[CH2:16]2)[CH2:12]1)[CH2:8][O:7][C:6]1[CH:28]=[CH:29][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1
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참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 116512251-(2-Bromoethyl)pyrroleHCID 86588969tert-butyl (1S)-2-(4-cyanophenoxy)-1-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-ylmethyl)ethylcarbamate

생성물 1

HCID 684557444-[((2S)-2-Amino-3-{7-[2-(1H-pyrrol-1-yl)ethyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl}propyl)oxy]benzonitrile수율 90.7%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A mixture of tert-butyl (1S)-2-(4-cyanophenoxy)-1-(9-oxa-3,7-diaza-bicyclo[3.3.1]non-3-ylmethyl)ethylcarbamate (Preparation J; 100.62 mg, 0.25 mmol), 1-(2-bromoethyl)pyrrole (52.21 mg, 0.30 mmol) and TEA (37.9 mg, 0.375 mmol) in DMF (2.5 mL) was stirred at rt for 2 days and then at 50° C. for 1 day. The solvent was evaporated and the resulting residue dissolved in ethyl acetate (0.5 mL). Ethyl acetate saturated with gaseous hydrochloric acid (2 mL) was added, and the reaction mixture stirred for 1.5 h at rt. The solvent was evaporated and the resulting residue dissolved in a mixture of MeCN (2.5 mL) and H2O (0.13 mL). Potassium carbonate (100 mg, 0.72 mmol) was added, and the mixture stirred overnight at rt. The mixture was filtered and the filtrate concentrated in vacuo. The resulting crude product was dissolved in DCM (2 mL), which solution was added to a ion-exchange solid-phase extraction plug (CBA, 2 g). After 80 min, the product was eluted with DCM:MeCN (4×2 mL of 4:1), followed by DCM:MeOH:TEA (8:1:1), to give 89.7 mg (90.7%) of the title compound.

후처리

  1. waitat 50° C. for 1 day
  2. customThe solvent was evaporated
  3. dissolutionthe resulting residue dissolved in ethyl acetate (0.5 mL)
  4. additionEthyl acetate saturated with gaseous hydrochloric acid (2 mL) was added
  5. stirringthe reaction mixture stirred for 1.5 h at rt
  6. customThe solvent was evaporated
  7. dissolutionthe resulting residue dissolved in a mixture of MeCN (2.5 mL) and H2O (0.13 mL)
  8. stirringthe mixture stirred overnight at rt
  9. filtrationThe mixture was filtered
  10. concentrationthe filtrate concentrated in vacuo
  11. dissolutionThe resulting crude product was dissolved in DCM (2 mL)
  12. additionwhich solution was added to a ion-exchange solid-phase extraction plug (CBA, 2 g)
  13. waitAfter 80 min
  14. washthe product was eluted with DCM

출처 및 근거

ORD 기록
ord-1e651fd6de3f4ef7a6c915f051ab9dc6
출처 데이터셋
uspto-grants-2007_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07164017B2

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