Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1374244노트

반응식

HRID 1374244 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

생성물 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinato수율 71.5%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6344Dichloromethane용매

실험 절차

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

후처리

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

출처 및 근거

ORD 기록
ord-51fc4c6ac0ba46bd9f7bff9ec20eb53f
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07163937B2

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