Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylcarbamoyl Chloride → 4-Pentyl-2-cyanopyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| 반응물 | Trimethylsilyl cyanide | HCID 82115 | — |
| 반응물 | 4-(Benzyloxy)pyridine N-oxide | HCID 295871 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Pentyl-2-cyanopyridine | HCID 21076083 | 100% |
반응 단계
To trimethylsilyl cyanide (5.2 g, 52 mmol), 4-benzyloxy-pyridine 1-oxide (8.8 g, 44 mmol) in DCM (20 mL) was added, followed by dimethylcarbamoyl chloride (5.6 g, 52 mmol) in DCM (10 mL), dropwise, stirred at room temperature overnight. Sodium bicarbonate (100 mL, 10%) was added, stirred for 10 minutes and extracted twice with DCM (50 mL). The combined organic layer was dried over magnesium sulfate, solvent was removed to obtain the product, compound 10a (R9=Benzyloxy) (10.5 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07164011B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-8ff36099531048408abe54de9026d0ee |
| 출처 메모 | uspto-grants-2007_01 |