Glutaric anhydride → 5-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid

HRID 1374587노트

반응식

HRID 1374587 반응식
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[N:9]1([CH2:15][C:16]([N:18](C)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:17])[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.O1CCOC[CH2:27]1>>[CH3:27][CH:15]([C:16](=[O:17])[NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[N:9]1[CH2:14][CH2:13][N:12]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:11][CH2:10]1

참가 물질

4

반응물 3

HCID 7940Glutaric anhydrideHCID 312751,4-DioxaneHCID 2737187N-methyl-N-phenyl-2-(piperazin-1-yl)acetamide

생성물 1

HCID 695033575-[4-(Methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid

반응 조건

온도
25 °C

실험 절차

1.517 g of glutaric anhydride and then 1.715 g of N-[2-(piperazin-1-yl)acetyl]-N-methylaniline are added to 15 cm3 of dioxane. After stirring for 19 hours at 25° C., the white precipitate formed is filtered on No. 4 sintered glass, rinsed with dioxane and then with diethyl ether and then dried at 20° C. (90 Pa) to give 2 g of 5-[4-(methylphenylcarbamoylmethyl)piperazin-1-yl]-5-oxopentanoic acid in the form of a white solid which is used as it is.

후처리

  1. customthe white precipitate formed
  2. filtrationis filtered on No
  3. wash4 sintered glass, rinsed with dioxane
  4. dry with materialwith diethyl ether and then dried at 20° C. (90 Pa)

출처 및 근거

ORD 기록
ord-39a99c2913fe4965814b43325565eac7
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166594B2

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