[Methyl-(toluene-4-sulfonyl)-amino]-acetic acid → HCID 20582824, 화합물

HRID 1374605

반응식

HRID 1374605 반응식
[C:1]1([CH3:16])[CH:6]=[CH:5][C:4]([S:7]([N:10]([CH2:12][C:13]([OH:15])=O)[CH3:11])(=[O:9])=[O:8])=[CH:3][CH:2]=1.Cl.Cl.C[O:20][C:21](=[O:31])[C@H:22]([CH2:24][C:25]1[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=1)[NH2:23]>>[C:1]1([CH3:16])[CH:2]=[CH:3][C:4]([S:7]([N:10]([CH2:12][C:13]([NH:23][C@H:22]([C:21]([OH:31])=[O:20])[CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[O:15])[CH3:11])(=[O:8])=[O:9])=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 802555[Methyl-(toluene-4-sulfonyl)-amino]-acetic acidHCID 46862166H-Ala(3-pyridyl)-OMe.2HCl

생성물 1

HCID 20582824HCID 20582824, 화합물수율 17%

실험 절차

N-(Toluene-4-sulfonyl)sarcosine was coupled to 3-(3-pyridyl)alanine methyl ester dihydrochloride using the procedure described in Method 3 to give N-(toluene-4-sulfonyl)sarcosyl-β-(3-pyridyl)alanine (166 mg, 17%). The title compound was prepared via hydrolysis of the methyl ester using 1N aqueous NaOH in dioxane/water (129 mg, 100%).

출처 및 근거

ORD 기록
ord-01c09ea1fc624e848211ad1dc4ed17dc
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166580B2

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