Water → 5-Fluoro-2-(trifluoromethyl)phenylacetonitrile

HRID 1374626노트

반응식

HRID 1374626 반응식
[C-:1]#[N:2].[K+].[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH:12]=1)[CH2:10]Br.O>C(O)C.C(OCC)(=O)C>[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH2:10][C:1]#[N:2])[CH:12]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 9032Potassium CyanideHCID 27375785-Fluoro-2-(trifluoromethyl)benzyl bromide

생성물 1

HCID 27376045-Fluoro-2-(trifluoromethyl)phenylacetonitrile

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

1.95 g (30 mmol) of potassium cyanide is added to a solution of 5.14 g (20 mmol) of 5-fluoro-2-trifluoromethylbenzyl bromide in 45 ml of ethanol/8 ml of water, and it is stirred for 64 hours at room temperature. The reaction solution is diluted with ethyl acetate and extracted with saturated sodium bicarbonate solution. The organic phase is washed with water, dried and concentrated by evaporation. The remaining residue is purified by bulb tube distillation and recrystallized. Yield: 3.6 g (89%).

후처리

  1. extractionextracted with saturated sodium bicarbonate solution
  2. washThe organic phase is washed with water
  3. customdried
  4. concentrationconcentrated by evaporation
  5. customThe remaining residue is purified by bulb tube
  6. distillationdistillation
  7. customrecrystallized

출처 및 근거

ORD 기록
ord-2f81eee98c95417489e7276c8f592b6a
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166592B2

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