4-(Aminomethyl)piperidine → tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)

HRID 1374828노트

반응식

HRID 1374828 반응식
NCC1CCNCC1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1

참가 물질

5

반응물 3

HCID 235274-(Aminomethyl)piperidineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 21866389Hydrogen chloride-ethyl acetate

생성물 1

HCID 2756034tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)수율 82%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

By using 4-aminomethylpiperidine 5.71 g as a starting material, tert-butyl 4-aminomethylpiperidine-1-carboxylate was prepared according to the method described in Synthetic Commun., 22(16), 2357–2360 (1992). The resulting compound was dissolved in 80 ml of ethyl acetate, and the solution was added with 4N hydrogen chloride-ethyl acetate and stirred. The precipitated solids were collected by filtration to obtain the title compound (10.27 g, yield: 82%).

후처리

  1. customwas prepared
  2. filtrationThe precipitated solids were collected by filtration

출처 및 근거

ORD 기록
ord-2ddb96259e7d41479389f7fbc4da843d
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166617B2

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