Chloroacetyl chloride → 2-chloro-N,N-diphenyl-Acetamide

HRID 1374837

반응식

HRID 1374837 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]1([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1.O1CCCC1>[Cl:1][CH2:2][C:3]([N:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

참가 물질

5

반응물 2

HCID 6577Chloroacetyl chlorideHCID 11487Diphenylamine

생성물 1

HCID 2244812-chloro-N,N-diphenyl-Acetamide수율 75.5%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

Chloroacetyl chloride (0.32 ml, 4.02 mmol) was dissolved in a mixed solvent of toluene (6 ml) and tetrahydrofuran (2 ml). The solution was added with diphenylamine (690 mg, 4.08 mmol) at room temperature, and the heated at 100° C. for 80 minutes. The solvent was evaporated under reduced pressure, and the solid precipitated was suspended and washed in ethyl ether. The solid was collected by filtration and dried under reduced pressure to obtain the title compound as colorless solid (746 mg, yield: 75%).

후처리

  1. customThe solvent was evaporated under reduced pressure
  2. customthe solid precipitated
  3. washwashed in ethyl ether
  4. filtrationThe solid was collected by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-f223e951be944d738507469f0bceee6f
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166617B2

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