Acetone → 1937215-88-7

HRID 1374854노트

반응식

HRID 1374854 반응식
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.O.CC(C)=[O:32]>C(OCC)(=O)C>[OH2:27].[OH2:32].[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:12][CH2:13][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:15][CH2:16]2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 180AcetoneHCID 962WaterHCID 21078079359625-80-22회

생성물 1

HCID 210780801937215-88-7수율 79%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
60 °C

실험 절차

2-[[1-[2-(4-Fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]isoindolin-1-one hydrochloride (the compound of Example 1, 39.4 mmol) was added to water (30 mL) and acetone (210 mL), and mixture was heated at 60° C. for dissolution. The mixture was added dropwise with ethyl acetate (100 mL) and stand for cooling to room temperature. The crystals precipitated were collected by filtration and the resulting crystals were washed with ethyl acetate and dried under reduced pressure to obtain the title compound (yield: 79%).

후처리

  1. temperaturefor cooling to room temperature
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washthe resulting crystals were washed with ethyl acetate
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-fb872da5c1e5452ab3504350e2f68b5d
출처 데이터셋
uspto-grants-2007_01
특허 번호
US07166617B2

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