2-(5-Bromo-3-pyridyloxy)butyric acid → 2-(5-bromo-3-pyridyloxy)-N-(2-methylhex-3-yn-2-yl)butyramide
반응식
Cl.[NH2:2][C:3]([CH3:9])([CH3:8])[C:4]#[C:5][CH2:6][CH3:7].[Br:10][C:11]1[CH:12]=[C:13]([O:17][CH:18]([CH2:22][CH3:23])[C:19](O)=[O:20])[CH:14]=[N:15][CH:16]=1>>[Br:10][C:11]1[CH:12]=[C:13]([O:17][CH:18]([CH2:22][CH3:23])[C:19]([NH:2][C:3]([CH3:9])([C:4]#[C:5][CH2:6][CH3:7])[CH3:8])=[O:20])[CH:14]=[N:15][CH:16]=1참가 물질
3
실험 절차
This compound was prepared using a similar procedure to that described in Stage 3 of Example 1 except that 5-amino-5-methylhex-3-yne hydrochloride was used in place of 4-amino-4-methylpent-2-yne hydrochloride and 2-(5-bromo-3-pyridyloxy)butyric acid was used in place of 2-(5-chloro-3-pyridyloxy)butyric acid. The compound was characterised as follows: colourless solid, m.p. 90–92° C.; 1H NMR (CDCl3) δ: 1.02–1.06 (3H, t); 1.10–1.14 (3H, t); 1.62 (6H, s); 1.96–2.02 (2H, m); 2.16–2.22 (2H, m); 4.424.46 (1H, m); 6.30 (1H, br s); 7.40 (1H, m); 8.30 (1H, d); 8.36 (1H, d).
후처리
- customThis compound was prepared