methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate → 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

HRID 13755노트

반응식

HRID 13755 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:21])[C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH3:20])[CH3:19])[CH2:14]1)[C:5]([O:7]C)=[O:6]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:21])[C:11]=1[CH2:12][N:13]1[CH2:17][CH2:16][C@H:15]([N:18]([CH3:19])[CH3:20])[CH2:14]1)[C:5]([OH:7])=[O:6]

참가 물질

3

반응물 1

HCID 68694023methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate

생성물 1

HCID 686902813,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

This compound was prepared in the same manner as in Reference Example 1 (step 6), except that methyl 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoate obtained in the step 3 was used and methanol was used as the solvent, and that after methanol was added to the residue and the resulting mixture was stirred, insolubles were removed by filtration and the solvent in the filtrate was distilled off under reduced pressure to obtain the objective compound.

후처리

  1. customobtained in the step 3
  2. custominsolubles were removed by filtration
  3. distillationthe solvent in the filtrate was distilled off under reduced pressure
  4. customto obtain the objective compound

출처 및 근거

ORD 기록
ord-b7e88198fb3f4159871c12ceae7412d9
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728131B2

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