Thionyl Chloride → HCID 86625063, 화합물

HRID 13756노트

반응식

HRID 13756 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5](O)=[O:6].S(Cl)([Cl:23])=O>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5]([Cl:23])=[O:6]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 686902813,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

생성물 1

HCID 86625063HCID 86625063, 화합물

실험 절차

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid obtained in the step 4 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

후처리

  1. customobtained in the step 4
  2. distillationwas distilled off under reduced pressure
  3. additionthe operation of adding of toluene to the residue
  4. customfollowed by azeotropic removal of thionyl chloride

출처 및 근거

ORD 기록
ord-51a8e10028bf4ad2bbe3361dd4f7becc
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728131B2

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