Potassium Carbonate → HCID 58786151, 화합물
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C([SiH](CC)CC)C.[CH2:8]([O:15][C@@H:16]1[C@@H:22]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C@H:21]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C@@H:20]([CH2:39][O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[O:19][C:17]1([C:48]1[CH:53]=[C:52]([CH3:54])[CH:51]=[CH:50][C:49]=1[O:55][CH2:56][CH3:57])O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:8]([O:15][C@@H:16]1[C@@H:22]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C@H:21]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C@@H:20]([CH2:39][O:40][CH2:41][C:42]2[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=2)[O:19][C@H:17]1[C:48]1[CH:53]=[C:52]([CH3:54])[CH:51]=[CH:50][C:49]=1[O:55][CH2:56][CH3:57])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1참가 물질
4
실험 절차
Boron trifluoride-diethyl ether complex (0.6 ml) and triethylsilane (1.7 ml) were added dropwise to a solution of 2,3,4,6-tetra-O-benzyl-1-C-(2-ethoxy-5-methylphenyl)-D-glucopyranose (3.5 g) at −50° C. and the mixture was stirred for two hours. Saturated aqueous solution of potassium carbonate was added to the reaction mixture and the mixture was extracted with chloroform. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain (1S)-1,5-anhydro-2,3,4,6-tetra-O-benzyl-1-(2-ethoxy-5-methylphenyl)-D-glucitol (3.4 g).
후처리
- extractionthe mixture was extracted with chloroform
- washThe organic layer was washed with saturated brine
- dry with materialdried over anhydrous sodium sulfate
- filtrationAfter filtration
- concentrationthe filtrate was concentrated
- customThe residue was purified by silica gel column chromatography (hexane-ethyl acetate)
출처 및 근거
- ORD 기록
- ord-1a44c6cd78834a85976a814b42185d94
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07169761B2
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