tert-Butyl bromoacetate → tert-Butyl 3-amino-1H-indole-2-carboxylate

반응식

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9]C(=O)C(F)(F)F)#[N:2].Br[CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]>>[NH2:2][C:1]1[C:3]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:9][C:17]=1[C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19]

참가 물질

반응물 2

HCID 79177tert-Butyl bromoacetate

HCID 9203669HCID 9203669, 화합물

생성물 1

HCID 19360138tert-Butyl 3-amino-1H-indole-2-carboxylate

실험 절차

Follow the procedure of Example 3 (Steps B3–B5) but start with N-(2-cyano-phenyl)-2,2,2-trifluoroacetamide (synthesis described in J. Fluorine Chem. 1981, 18, (2), 185–95) and tert-butyl bromoacetate to obtain the title compound: MS 310(M+H), TLC (silica gel, dichloromethane/methanol, 7:1) Rf=0.38.

출처 및 근거

ORD 기록: ord-fca8227adf7b42cdaf49f66008a2082d
출처 데이터셋: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07169925B2

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