Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3,3-Dimethylbutyl 3-piperidinopropyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | 1-Chloro-3,3-dimethylbutane | HCID 76111 | — |
| 반응물 | Sodium 3-piperidinopropanolate | HCID 23694275 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 3,3-Dimethylbutyl 3-piperidinopropyl ether | HCID 9794557 | — |
반응 단계
Sodium 3-piperidinopropanolate (5 mmol), 5 mmol of 3,3-dimethylbutyl chloride, a catalytic amount of tetrabutylammonium iodide, and 0.5 mmol of 15-crown-5 in 10 ml of dry dimethyl sulfoxide were refluxed for 12 hours. Water was added, and it was extracted with diethyl ether. The organic layer was purified by column chromatography on silica gel (eluent: methylene chloride/methanol (90/10), ammonia atmosphere). The solvent was removed under reduced pressure and the residue crystallized with oxalic acid from diethyl ether/ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07169928B2 |
| 출처 데이터셋 | uspto-grants-2007_01 |
| ORD ID | ord-8d5875571de64e99b721756f1b8bfbe6 |
| 출처 메모 | uspto-grants-2007_01 |