2-Chlorobenzothiazole → 2-Benzothiazolyl 3-piperidinopropyl ether
반응식
[N:1]1([CH2:7][CH2:8][CH2:9][O-:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Na+].Cl[C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1>O1CCCC1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
Sodium 3-piperidinopropanolate (5 mmol) and 5 mmol of 2-chlorobenzothiazole in 20 ml of dry tetrahydrofurane were refluxed for 12 hours. The suspension was filtered and the solvent evaporated under reduced pressure. The product was crystallized with oxalic acid from diethyl ether/ethanol.
후처리
- filtrationThe suspension was filtered
- customthe solvent evaporated under reduced pressure
- customThe product was crystallized with oxalic acid from diethyl ether/ethanol
출처 및 근거
- ORD 기록
- ord-a98bbd0eb38a47ea9a963177e9862ba4
- 출처 데이터셋
- uspto-grants-2007_01
- 특허 번호
- US07169928B2
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