Water → 3-Bromo-5-tert-butylamino-1-methyl-4-nitropyrazole

HRID 1376880노트

반응식

HRID 1376880 반응식
[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5](Br)[N:4]([CH3:11])[N:3]=1.[C:12]([NH2:16])([CH3:15])([CH3:14])[CH3:13].O>C(O)C>[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([NH:16][C:12]([CH3:15])([CH3:14])[CH3:13])[N:4]([CH3:11])[N:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 229186383,5-Dibromo-1-methyl-4-nitro-1H-pyrazole

생성물 1

HCID 229186363-Bromo-5-tert-butylamino-1-methyl-4-nitropyrazole수율 78%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1.5 g (5.26 mmoles) of 3,5-dibromo-1-methyl-4-nitropyrazole are heated in a solution of 20 ml tert-butylamine in 30 ml ethanol for 20 hours at boiling temperature. After cooling, the reaction mixture is poured on 150 ml water, the separated product is filtered and washed with 100 ml water. After vacuum drying, 1.14 g (78 percent of theory) of 3-bromo-5-tert-butylamino-1-methyl-4-nitropyrazole are obtained in the form of pale yellow flakes with a melting point of 75° to 77° C.

후처리

  1. temperatureAfter cooling
  2. filtrationthe separated product is filtered
  3. washwashed with 100 ml water
  4. customAfter vacuum drying

출처 및 근거

ORD 기록
ord-43088b64693c4cccbbd6a2c1eb4dfd17
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05663366

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