Ethylamine → 1-Benzyl-3-bromo-5-ethylamino-4-nitropyrazole

반응식

[CH2:1]([N:8]1[C:12](Br)=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([NH2:20])[CH3:19]>>[CH2:1]([N:8]1[C:12]([NH:20][CH2:18][CH3:19])=[C:11]([N+:14]([O-:16])=[O:15])[C:10]([Br:17])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 6341Ethylamine

HCID 196972381-benzyl-3,5-dibromo-4-nitro-1H-pyrazole

생성물 1

HCID 229186321-Benzyl-3-bromo-5-ethylamino-4-nitropyrazole수율 89%

실험 절차

3.61 (10 mmoles) of 1-benzyl-3,5-dibromo-4-nitropyrazole are heated at 60° C. in 120 ml of a 30-percent aqueous ethylamine solution for 1 hour. After cooling, the product separates in the form of colorless crystals with a melting point of 122° C. 2.88 g (89 percent of theory) of 1-benzyl-3-bromo-5-ethylamino-4-nitropyrazole are obtained.

후처리

temperatureAfter cooling

출처 및 근거

ORD 기록: ord-1c0db043f5f44541b951f60166c82328
출처 데이터셋: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05663366

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