Thionyl Chloride → HCID 21221127, 화합물

HRID 1377188노트

반응식

HRID 1377188 반응식
[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4]O.C1OC2C=CC(C[Cl:19])=CC=2O1.S(Cl)(Cl)=O>CCOCC>[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4][Cl:19]

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 887131,3-Benzodioxole, 5-(chloromethyl)-HCID 43971742,3-Dimethyl-4-methoxybenzyl alcohol

생성물 1

HCID 21221127HCID 21221127, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

1 g (6.016 mmol) of 2,3-dimethyl-4-methoxybenzyl alcohol (Aldrich, Steinheim, FRG) and 4.8 g of diisopropylaminomethylpolystyrene (polyhunig base, see Ex. 44a) in 21 ml of abs. ether are treated dropwise, at from 0° C. to 5° C. and over the space of approximately 25 min, with 0.482 ml of thionyl chloride. After the reaction has ended, the mixture is filtered with suction and the solvent and the excess reagent are removed. The residue, which is the desired title compound, is subjected, without purification, to further processing. TLC Rf (hexane:ethyl acetate 4:1)=0.59. IR(CH2Cl2) inter alia: 1599, 1485, 1466 und 1107 cm-1. 1H-NMR (200 MHz, CDCl3): 7.14 (d, 1H); 6.69 (d, 1H); 4.64 (s, 2H); 3.82, 2.34 and 2.18 (each s, each 3H).

후처리

  1. filtrationthe mixture is filtered with suction
  2. customthe solvent and the excess reagent are removed
  3. customis subjected, without purification, to further processing

출처 및 근거

ORD 기록
ord-9149e4903598427287ac57559a58efc6
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05663200

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