Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Ethyl Ketone → 4-[4-[2-(1,3-Dioxolan-2-yl)ethyl]phenoxyacetyl]-5-methyl-2-phenyloxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Ethyl Ketone | HCID 6569 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-one | HCID 14913650 | — |
| 반응물 | 4-[2-(1,3-Dioxolan-2-yl)ethyl]phenol | HCID 18546139 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-[4-[2-(1,3-Dioxolan-2-yl)ethyl]phenoxyacetyl]-5-methyl-2-phenyloxazole | HCID 18546170 | 57% |
반응 단계
A mixture of 4-bromoacetyl-5-methyl-2-phenyloxazole (2.60 g), 4-[2-(1,3-dioxolan-2-yl)ethyl]phenol (1.82 g), potassium carbonate (1.28 g) and 2-butanone (60 ml) was stirred for 20 hours at temperatures ranging from 70° to 80° C. The reaction mixture was poured into water. Resulting crystalline precipitate was collected by filtration, which was purified by means of a silica gel column chromatography. From the fractions eluted with chloroform-methanol (100:1, v/v), 4-[4-[2-(1,3-dioxolan-2-yl)ethyl]phenoxyacetyl]-5-methyl-2-phenyloxazole (2.08g, 57%) was obtained. Recrystallization from dichloromethane--isopropyl ether gave colorless prisms, m.p.119°-120° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05665748 |
| 출처 데이터셋 | uspto-grants-1997_09 |
| ORD ID | ord-30679ba5027847959ad4552defb01dd5 |
| 출처 메모 | uspto-grants-1997_09 |