1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one → 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

HRID 1377687

반응식

HRID 1377687 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]2=[O:23])[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[Pd+2].[OH-].CO>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]2=[O:23])[CH2:10][CH2:9]1

참가 물질

4

반응물 1

HCID 36559951-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one

생성물 1

HCID 27611521-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A solution of 10 ml of methanol containing 296 mg of 1-(1-benzyl-4-piperidyl)indol-2-one was treated with 300 mg of palladium hydroxide catalyst. The resulting suspension was hydrogenated at atmospheric pressure for 60 minutes at 23° C. More catalyst was added (100 mg) and the hydrogenation was continued for 30 minutes more. The reaction mixture was filtered through Celite, concentrated and azeotropically dried with toluene to yield 217 mg of 1-(4-piperidyl)indol-2-one.

후처리

  1. additionMore catalyst was added (100 mg)
  2. waitthe hydrogenation was continued for 30 minutes
  3. filtrationThe reaction mixture was filtered through Celite
  4. concentrationconcentrated
  5. dry with materialazeotropically dried with toluene

출처 및 근거

ORD 기록
ord-ee99e36bb8b24fd0801d8ba1d9469d7f
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05665719

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