1-Benzylpiperazine → 1-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

HRID 1378329

반응식

HRID 1378329 반응식
[O:1]([C:8]([CH3:13])([CH3:12])[C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:14]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[O:1]([C:8]([CH3:13])([CH3:12])[C:9]([N:24]1[CH2:25][CH2:26][N:21]([CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:22][CH2:23]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 759941-BenzylpiperazineHCID 131111912-Methyl-2-phenoxypropanoyl chloride

생성물 1

HCID 106169921-(2-Phenoxy-2-methylpropionyl)-4-benzylpiperazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 0.01 mol of 2-phenoxyisobutyric acid chloride (obtained by reaction of thionyl chloride with 2-phenoxyisobutyric acid) in 100 ml of methylene chloride is introduced into an Erlenmeyer flask containing a solution of 0.01 mol of 1-benzylpiperazine in 100 ml of methylene chloride. The mixture is stirred for 5 hours at room temperature, filtered and evaporated to dryness. The residue is taken up in water, basified and extracted with chloroform. The organic phases are combined, dried and evaporated.

후처리

  1. filtrationfiltered
  2. customevaporated to dryness
  3. extractionextracted with chloroform
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-3bcfaea19aaf46f69f08e67cfa8e5548
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668138

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