Potassium Carbonate → 1,5-Bis(4-(2-quinolylmethoxy)phenyl)-3-pentanone

HRID 1378398노트

반응식

HRID 1378398 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:20])[CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:28][C:29]1[CH:38]=[CH:37][C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[N:30]=1>CN(C=O)C>[N:30]1[C:31]2[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:37]=[CH:38][C:29]=1[CH2:28][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:20])[CH2:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:28][C:29]3[CH:38]=[CH:37][C:36]4[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=4)[N:30]=3)=[CH:17][CH:18]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 203942-(Chloromethyl)quinolineHCID 107071713-Pentanone, 1,5-bis(4-hydroxyphenyl)-

생성물 1

HCID 107928071,5-Bis(4-(2-quinolylmethoxy)phenyl)-3-pentanone수율 113.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 1,5-bis(4-hydroxyphenyl)-3-pentanone (2.0 g, 8 mmol), prepared as in step 2, and potassium carbonate (2.76 g, 20 mmol) in DMF (40 mL) was treated with chloromethylquinoline (3.55 g, 20 mmol) at room temperature for 36 hours. The mixture was then poured into ice water (200 mL), and the precipitated solid was filtered, washed with water and dried in vacuo to afford crude 1,5-bis(4-(2-quinolylmethoxy)phenyl)-3-pentanone (5 g) which was used without further purification.

후처리

  1. filtrationthe precipitated solid was filtered
  2. washwashed with water
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-9e9113ccc329412ab5502953c0663ff9
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668146

반응 노트

불러오는 중…