Dimethylamine → N,N-dimethyl-3-nitropyridin-2-amine
반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:11][NH:12][CH3:13].O>CCO>[CH3:11][N:12]([CH3:13])[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1참가 물질
5
실험 절차
A stirred mixture of 2-chloro-3-nitropyridine (1.00 g, 0.00631 mol) in absolute EtOH (17 ml), under nitrogen, was treated, dropwise during 10 minutes, with 3.86 g (0.0214 mol) of 25% aqueous dimethylamine and kept at ambient temperature (25° C.) for 30 minutes. The mixture was mixed with water and extracted with EtOAc. The extract was washed with water, dried (MgSO4) and concentrated to give 1.05 g of the titled product, a yellow oil.
후처리
- customkept at ambient temperature
- custom(25° C.)
- customfor 30 minutes
- extractionextracted with EtOAc
- washThe extract was washed with water
- dry with materialdried (MgSO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-1ff17f8b64874cc1b3708b067b12b3b5
- 출처 데이터셋
- uspto-grants-1997_09
- 특허 번호
- US05668157
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