Iodine → 2-Benzyl-6-phenyl-isothiazolo[5,4-d]pyrimidin-3-one

HRID 1378486

반응식

[CH2:1]([NH:8][C:9]([C:11]1[C:12]([SH:23])=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.II>>[CH2:1]([N:8]1[C:9](=[O:10])[C:11]2[C:12](=[N:13][C:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[N:15][CH:16]=2)[S:23]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 807Iodine

HCID 178418303HCID 178418303, 화합물

생성물 1

HCID 232879022-Benzyl-6-phenyl-isothiazolo[5,4-d]pyrimidin-3-one수율 87.6%

실험 절차

Using the procedure of Example 20, 2.0 g (6.22 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid benzylamide (from Preparation 42) was reacted with 1.74 g (6.8 mmol) of iodine to give 1.74 g of the title compound after crystallization from isopropanol, mp 166°-167° C.

출처 및 근거

ORD 기록: ord-6f1a429b58ec427eb7086aa497bd0df0
출처 데이터셋: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05668162

연결된 노트

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