Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 4-Mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide | HCID 178418292 | — |
| 생성물 | 2-(2-Morpholin-4-yl-ethyl)-6-phenyl-isothiazolo[5,4-d)pyrimidin-3-one | HCID 23287882 | 60.8% |
반응 단계
Using the procedure of Example 20, 2.0 g (5.81 mmol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide were treated with 1.47 g (5.81 mmol) of iodine to give 1.21 g of the title compound after recrystallization from isopropanol, mp 163°-165° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05668162 |
| 출처 데이터셋 | uspto-grants-1997_09 |
| ORD ID | ord-42a96ffb4f954b1896b9e9ea1551aa29 |
| 출처 메모 | uspto-grants-1997_09 |