Tetracaine Hydrochloride → Tetracaine

반응식

[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[O:13])=[CH:10][CH:11]=1.Cl.CCN(CCNC(C1C=C(Cl)C(N)=CC=1OC)=O)CC.O.Cl>>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[O:13])=[CH:8][CH:7]=1

참가 물질

반응물 2

HCID 8695Tetracaine Hydrochloride

HCID 441347Metoclopramide Hydrochloride

생성물 1

HCID 5411Tetracaine

실험 절차

The electrotransport of tetracaine HCl, in the form of an aqueous solution having a concentration of 100 mg/ml, was tested and found to behave similarly to that of metoclopramide HCl. The average mass flux obtained was 100 μg/cm2 hr, and there was a 1 to 2 hour time lag to reach steady state flux.

후처리

customThe average mass flux obtained

출처 및 근거

ORD 기록: ord-73861b78497641e79b1b25f48c5598b5
출처 데이터셋: uspto-grants-1997_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05668170

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