Ethyl chloroformate → 4-Indol-1-yl-piperidine-1-carboxylic acid ethyl ester

HRID 1378520노트

반응식

HRID 1378520 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl[C:24]([O:26][CH2:27][CH3:28])=[O:25]>C(Cl)Cl>[CH2:27]([O:26][C:24]([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH:16]=[CH:15]2)[CH2:10][CH2:9]1)=[O:25])[CH3:28]

참가 물질

4

반응물 2

HCID 10928Ethyl chloroformateHCID 212222251-Benzyl-4-(1-indolyl)-piperidine

생성물 1

HCID 140907494-Indol-1-yl-piperidine-1-carboxylic acid ethyl ester수율 53%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-N-(1-benzyl-piperidin-4-yl)-indole (100 g, 0.344 mol) in methylene chloride (1 L) was added ethyl chloroformate (99.2 mL) dropwise with stirring. The mixture was refluxed for 48 hours, cooled to room temperature, and concentrated. The residue was crystallized from i-propanol to give the title compound as colorless crystals (50 g, 53% yield). M.Pt.: 127° C.

후처리

  1. temperatureThe mixture was refluxed for 48 hours
  2. concentrationconcentrated
  3. customThe residue was crystallized from i-propanol

출처 및 근거

ORD 기록
ord-f170bc2b096f4c4a8bfda74f8ea4d2cb
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668152

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