Dichloromethane → 3-Phenylpropanethioamide
반응식
[C:1]1([CH2:7][CH2:8][C:9]([NH2:11])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:21])=CC=1.CCCCCC.C(Cl)Cl>C1(C)C=CC=CC=1.C(O)(=O)C>[C:1]1([CH2:7][CH2:8][C:9]([NH2:11])=[S:21])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
7
실험 절차
To a solution of 3-phenylpropionamide (1.653 g, 6.827 mmol) in toluene (20 mL) was added Lawesson's reagent (0.716 g, 1.77 mmol). The reaction was refluxed overnight, cooled to room temperature and concentrated yielding an orange oil. Flash chromatography of this oil (1:1 hexane:methylene chloride with 1% acetic acid) yielded 3-phenylthiopropionamide (0.070 g) as a white solid: mp 82°-83° C.; 1HNMR (DMSO d6) 300 mHz 9.35 (br s, 1 H), 9.15 (br s, 1 H), 7.34-7.10 (m, 2 H), 2.95 (t, J=8.48 Hz, 2 H), 2.72 (t, J=8.48 Hz, 2 H).
후처리
- temperatureThe reaction was refluxed overnight
- concentrationconcentrated
- customyielding an orange oil
출처 및 근거
- ORD 기록
- ord-7dec5218e5674c959072d8306e0cf727
- 출처 데이터셋
- uspto-grants-1997_09
- 특허 번호
- US05668161
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