Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 1378667노트

반응식

HRID 1378667 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4].S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:9]([Cl:18])=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

생성물 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.1 g (10 mmole) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmole) sulfuryl chloride and stirred for 10 minutes at room temperature. It was then concentrated and recrystallised from diisopropyl ether/ethyl acetate.

후처리

  1. concentrationIt was then concentrated
  2. customrecrystallised from diisopropyl ether/ethyl acetate

출처 및 근거

ORD 기록
ord-7c38228fbf9e450095e3de6a046e61e1
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05668278

반응 노트

불러오는 중…