Trifluoroacetic acid → (Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

HRID 1379115노트

반응식

HRID 1379115 반응식
F[C:2](F)(F)C([O-])=O.[NH:8]1[CH2:13][CH2:12][CH:11]([O:14][CH2:15][C:16]([OH:18])=[O:17])[CH2:10][CH2:9]1.FC(F)(F)C(O)=O.S(Cl)([Cl:28])=O>ClCCl.CO>[ClH:28].[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][CH2:15][C:16]([O:18][CH3:2])=[O:17])[CH2:12][CH2:13]1

참가 물질

7

반응물 4

HCID 6422Trifluoroacetic acidHCID 24386Thionyl ChlorideHCID 84468TrifluoroacetateHCID 184236272-(Piperidin-4-yloxy)acetic acid

생성물 1

HCID 21835549(Piperidin-4-yloxy)acetic acid methyl ester hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

By esterifying the trifluoroacetate of 4-piperidinyloxy-acetic acid (prepared by treating the product of Example 1c) with trifluoroacetic acid in dichloromethane) in methanol in the presence of thionyl chloride there is obtained methyl 4-piperidinyloxyacetate hydrochloride, MS (EI): 173 (M)+.

후처리

  1. customprepared

출처 및 근거

ORD 기록
ord-d6280c599f7d44fbb2172ace4875ab6b
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05670515

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