Acrylic Acid → 3-(2,3-Dichlorophenylthio)propanoic acid

HRID 1379132

반응식

HRID 1379132 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[SH:9].[C:10]([OH:14])(=[O:13])[CH:11]=[CH2:12]>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[S:9][CH2:12][CH2:11][C:10]([OH:14])=[O:13]

참가 물질

3

반응물 2

HCID 6581Acrylic AcidHCID 1402022,3-Dichlorobenzenethiol

생성물 1

HCID 218490133-(2,3-Dichlorophenylthio)propanoic acid수율 55.2%

반응 조건

온도
50 °C

실험 절차

2,3-Dichlorothiophenol (4.94 g, 28 mmol) was placed in a flask with acrylic acid (2.11 g, 29 mmol) and stirred at 50° C. for 3 hours. The reaction mixture was poured into 10% Na2Cl3 and extracted with ether. The aqueous layer was acidified with concentrated hydrochloric acid, extracted with ether, washed with brine, dried over MgSO4, and concentrated in vacuo to give the 3-(2,3-dichlorophenylthio)propanoic acid (3.88 g), contaminated with some acrylic acid, as a clear oil which was used without further purification in the next step.

후처리

  1. extractionextracted with ether
  2. extractionextracted with ether
  3. washwashed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8a1dc912a55a46fc8250c0c1b14ab645
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05670532

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