Hydrogen Peroxide → 2-Methyl-1-naphthol
반응식
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[CH3:12].CC1C=CC2C(=CC=CC=2)C=1B(O)[OH:25].B(O)O.OO>>[CH3:12][C:3]1[CH:4]=[CH:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]=1[OH:25]참가 물질
5
실험 절차
Yarboro, T. L.; Karr, C.; J. Org. Chem. 1959, 24, 1141 disclose a process wherein 1-bromo-2-methyl naphthalene is convened into 2-methyl-1-naphthalene boronic acid via Grignard reaction. The boronic acid is oxidized by 30% hydrogen peroxide to produce 2-methyl-1-naphthol in 51% yield. This prior art process is disadvantageous in that it involves 4 steps and is not economical.
출처 및 근거
- ORD 기록
- ord-bc2e5f0c465649e78684c16d15779377
- 출처 데이터셋
- uspto-grants-1997_09
- 특허 번호
- US05670698
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