Methyl Acrylate → 4-Morpholinepropanoic acid, methyl ester

HRID 1379395

반응식

HRID 1379395 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:7]([O:11][CH3:12])(=[O:10])[CH:8]=[CH2:9]>ClCCl>[N:1]1([CH2:9][CH2:8][C:7]([O:11][CH3:12])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 7294Methyl AcrylateHCID 8083Morpholine

생성물 1

HCID 1013734-Morpholinepropanoic acid, methyl ester수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 4.9 ml (56 mmol) of morpholine in 50 ml of dichloromethane was treated dropwise with 5.0 ml (56 mmol) of methyl acrylate. The resulting solution was allowed to stand at ambient temperature for 3 days, after which it was concentrated in vacuo to an oil. Chromatography on silica gel using 0.5% methanol/2% isopropylamine in chloroform provided 9.54 g (99%) of the desired compound as a colorless liquid.

후처리

  1. concentrationafter which it was concentrated in vacuo to an oil

출처 및 근거

ORD 기록
ord-26e81143862744a9b56f0ed9b6f2f8d3
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05670675

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