Formaldehyde → N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

HRID 1379573노트

반응식

HRID 1379573 반응식
[CH3:1][C:2]([NH2:12])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3].C=O.[C:15](=O)(O)[O-].[Na+]>>[CH2:15]=[N:12][C:2]([CH3:1])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3]

참가 물질

4

반응물 3

HCID 712FormaldehydeHCID 516892Sodium BicarbonateHCID 111950522-(3,5-Dichlorophenyl)propan-2-amine

생성물 1

HCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

실험 절차

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was gradually added to formalin (37% aqueous HCHO solution) (4.6 g) at room temperature. This mixture was subjected as it is to reaction for 7 hours. A saturated sodium bicarbonate solution was added to the reaction mixture, the resultant was extracted with ether and this organic layer was washed with saturated saline solution, and then dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure to obtain 8.6 g of N-methylene-1-methyl-1-(3,5-dichloro-phenyl)ethylamine as white crystals.

후처리

  1. customis to reaction for 7 hours
  2. extractionthe resultant was extracted with ether
  3. washthis organic layer was washed with saturated saline solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was removed by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-52a6716a7b1e4e29b01bd2b73c8beb15
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05672566

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