Methanesulfonic Acid → 5-Dimethylaminomethylfurfuryl chloride hydrochloride
반응식
[ClH:1].[CH3:2][N:3]([CH2:5][C:6]1[O:12][C:9]([CH2:10]O)=[CH:8][CH:7]=1)[CH3:4].S(Cl)([Cl:15])=O.CS(O)(=O)=O>C(#N)C>[ClH:15].[CH3:2][N:3]([CH2:5][C:6]1[O:12][C:9]([CH2:10][Cl:1])=[CH:8][CH:7]=1)[CH3:4]참가 물질
5
실험 절차
Combine 5-[(dimethylamino)methyl]-furfuryl alcohol hydrochloride (201 g, 1.05 mol) and acetonitrile (500 mL). Add dropwise, thionyl chloride (119 g, 1.0 mol) at such a rate that the temperature of the reaction is maintained at about 30° C. to 35° C. After the addition of thionyl chloride is complete, add methanesulfonic acid (144 g, 1.5 mol) while removing sulfur dioxide and acetonitrile by distillation. Stop the distillation when about 250 mL of distillate has been collected to give the title compound as a solution.
후처리
- additionAdd dropwise
- customwhile removing sulfur dioxide and acetonitrile
- distillationby distillation
- distillationthe distillation when about 250 mL of distillate
- customhas been collected
출처 및 근거
- ORD 기록
- ord-88d0520323934382803a9e351b4cb7bb
- 출처 데이터셋
- uspto-grants-1997_09
- 특허 번호
- US05672724
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