Methanesulfonic Acid → 5-Dimethylaminomethylfurfuryl chloride hydrochloride
반응식
[ClH:1].[CH3:2][N:3]([CH2:5][C:6]1[O:12][C:9]([CH2:10]O)=[CH:8][CH:7]=1)[CH3:4].S(Cl)([Cl:15])=O.CS(O)(=O)=O>C(#N)C>[ClH:15].[CH3:2][N:3]([CH2:5][C:6]1[O:12][C:9]([CH2:10][Cl:1])=[CH:8][CH:7]=1)[CH3:4]참가 물질
5
반응 조건
- 온도
- 10 °C
실험 절차
Combine 5-[(dimethylamino)methyl]-furfuryl alcohol hydrochloride (1.72 kg, 8.97 mol) and acetonitrile (4.3 L). Cool to about 10° C. Add thionyl chloride (1.02 kg, 8.54 mol) dropwise, while maintaining the temperature of the reaction at below about 40° C. After the addition of thionyl chloride is complete, add methanesulfonic acid (1.3 kg, 13.5 mol). Distill to remove about 1.8 L of distillate to give the title compound as a solution.
후처리
- customthe temperature of the reaction at below about 40° C
- distillationDistill
- customto remove about 1.8 L of distillate
출처 및 근거
- ORD 기록
- ord-82f011ea3df240f298bd03a1f2836efc
- 출처 데이터셋
- uspto-grants-1997_09
- 특허 번호
- US05672724
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