Methyl Acrylate → methyl 3-(N-vinylformamido)propionate

HRID 1379897

반응식

HRID 1379897 반응식
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=[CH2:3].[CH:7]([NH:9][CH:10]=[O:11])=[CH2:8]>C1(=O)C=CC(=O)C=C1.C[O-].[Na+]>[CH:7]([N:9]([CH2:3][CH2:2][C:1]([O:5][CH3:6])=[O:4])[CH:10]=[O:11])=[CH2:8]

참가 물질

5

반응물 2

HCID 7294Methyl AcrylateHCID 83191N-Vinylformamide

생성물 1

HCID 10964771methyl 3-(N-vinylformamido)propionate수율 92%

시약·촉매·용매 2

HCID 4650Quinone촉매HCID 10942334Sodium Methoxide촉매

실험 절차

To a 1000 mL three-neck round bottom flask equipped with a cold water condenser and stirrer was added 215 grams (2.5 moles) of methyl acrylate, 195 grams (2.75 moles) of N-vinylformamide, and 0.1 gram of benzoquinone. The mixture was stirred at ambient temperature for two minutes and 1.5 grams sodium methoxide was added in one portion. The mixture was stirred for approximately 2 hours at ambient temperature and allowed to stand overnight. The reaction mixture was distilled under vacuum and 361 grams of product (92% yield) boiling at 75° C. (0.8 mm Hg) was collected for analysis. 1H NMR analysis confirmed the identity of the 3-N-vinylformamido adduct.

후처리

  1. customTo a 1000 mL three-neck round bottom flask equipped with a cold water condenser and stirrer
  2. stirringThe mixture was stirred for approximately 2 hours at ambient temperature
  3. waitto stand overnight

출처 및 근거

ORD 기록
ord-94269b9c76ae47b491e8704996ee4077
출처 데이터셋
uspto-grants-1997_09
특허 번호
US05672731

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