HCID 13187346, 화합물 → HCID 13187347, 화합물

HRID 1379974노트

반응식

HRID 1379974 반응식
[CH3:1][O:2][Na].Cl[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[CH2:7]>CO>[CH3:1][O:2][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[CH2:7]

참가 물질

4

반응물 2

HCID 13187346HCID 13187346, 화합물HCID 178418582HCID 178418582, 화합물

생성물 1

HCID 13187347HCID 13187347, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a CH3ONa-solution from 6.9 g (0.3 gramatom) Na and 600 ml absolute CH3OH are added 59.3 g (0.3 Mol) 4(1-chloromethyl-ethenyl)-nitrobenzene, the reaction mixture heated under reflux for 2 hours and then evaporated to dryness. The residue is digested with diethylether, the ethereal solution filtered and the filtrate concentrated by evaporation. The residue is then chromatographed on silica gel (eluant n-hexane/diethylether 1:1) to give the title compound in analytically pure form (Rf=0.37 on silica gel with CHCl3).

후처리

  1. temperaturethe reaction mixture heated
  2. temperatureunder reflux for 2 hours
  3. customevaporated to dryness
  4. filtrationthe ethereal solution filtered
  5. concentrationthe filtrate concentrated by evaporation
  6. customThe residue is then chromatographed on silica gel (eluant n-hexane/diethylether 1:1)

출처 및 근거

ORD 기록
ord-a78641322b10404080059f284fba1f38
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579585

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