Acetic Acid → 2,3-Dihydro-1,4-benzodioxin-2-acetic acid

HRID 1380043

반응식

HRID 1380043 반응식
C(C[CH:4]1[O:9][C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[O:6][CH2:5]1)#N.[C:14]([OH:17])(=[O:16])[CH3:15].S(=O)(=O)(O)O>O>[O:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[O:9][CH2:4][CH:5]1[CH2:15][C:14]([OH:17])=[O:16]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 2675312-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile

생성물 1

HCID 2675342,3-Dihydro-1,4-benzodioxin-2-acetic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 175 g 2-cyanomethyl 1,4-benzodioxan, 250 ml water, 250 ml acetic acid and 100 ml concentrated sulphuric acid are heated to reflux for 48 hours. The reaction mixture is then poured in 5000 ml water and the whole is kept under stirring. The thus found crystalls are filtered, washed with water and dried, giving rise to 172 g (1,4-benzodioxan-2yl)acetic acid melting at 95°.

후처리

  1. temperatureare heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe thus found crystalls are filtered
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-f16d132e7bbe4e49b7993789be49112e
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579845

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