1-Isocyanato-4-methoxybenzene → Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

HRID 1380080

반응식

HRID 1380080 반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1>C(OCC)C.C(N(CC)CC)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:21])[O:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:10]=2[NH:9][CH:8]=[CH:7]3)=[CH:15][CH:14]=1

참가 물질

5

반응물 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 27376517-Hydroxyindole

생성물 1

HCID 20242122Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8471Triethylamine용매

실험 절차

To a solution of 7-hydroxyindole (0.7 g.) in ethyl ether (25 ml) and triethylamine (1 ml) is added 0.8 g. 4-methoxyphenyl isocyanate (Aldrich 23860-0). The reaction is stirred for 3 days at room temperature. The solvent is removed in vacuo and the remaining oil is purified by HPLC on silica gel.

후처리

  1. customThe solvent is removed in vacuo
  2. customthe remaining oil is purified by HPLC on silica gel

출처 및 근거

ORD 기록
ord-0d3d79ab1fce4551a70c6636a84fdf01
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579865

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