Piperazine → 1-(3-Piperazinylpropyl)-3-n-hexylurea

HRID 1380199노트

반응식

HRID 1380199 반응식
Cl[CH2:2][CH2:3][CH2:4][NH:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:7].[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>C(O)C>[N:15]1([CH2:2][CH2:3][CH2:4][NH:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[O:7])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 136067321-(3-Chloropropyl)-3-n-hexylurea

생성물 1

HCID 571432471-(3-Piperazinylpropyl)-3-n-hexylurea수율 39%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1-(3-chloropropyl)-3-n-hexylurea (11.0 g; 50 mmole), piperazine (43.0 g; 500 mmole) and reagent ethanol (250 ml) was refluxed for 2 hours. The solvent was removed in vacuo, and the solid residue was dissolved in water. The resulting solution was extracted with methylene chloride, concentrated in vacuo, and the residue was chromatographed on silica gel to give 1-(3-piperazinylpropyl)-3-n-hexylurea as a light yellow oil (6.7 g; 39% yield).

후처리

  1. temperaturewas refluxed for 2 hours
  2. customThe solvent was removed in vacuo
  3. dissolutionthe solid residue was dissolved in water
  4. extractionThe resulting solution was extracted with methylene chloride
  5. concentrationconcentrated in vacuo
  6. customthe residue was chromatographed on silica gel

출처 및 근거

ORD 기록
ord-d0f86b9766324726a753e3dba896e77d
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04579947

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