Urea → HCID 178488789, 화합물

HRID 1380508노트

반응식

HRID 1380508 반응식
[NH2:1][C:2]([NH2:4])=[O:3].CC[O-].[Na+].CN(C)[CH:11]=[C:12]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)[C:13](=O)[CH3:14]>C(O)C>[CH3:23][O:22][C:19]1[CH:20]=[CH:21][C:16]([C:12]2[C:13]([CH3:14])=[N:1][C:2](=[O:3])[NH:4][CH:11]=2)=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 1176UreaHCID 2723922Sodium ethoxideHCID 539901024-Dimethylamino-3-(4-methoxyphenyl)-3-buten-2-one

생성물 1

HCID 178488789HCID 178488789, 화합물수율 49.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
0 °C

실험 절차

24.4 g of urea and 120 ml of a 25 percent ethanolic solution of sodium ethylate are added to a solution of 40.0 g of 4-dimethylamino-3-(4-methoxyphenyl)-3-buten-2-one in 120 ml of ethanol. The mixture is heated at the reflux temperature for 8 hours, then cooled to 0° C., and the reaction product is filtered off with suction and washed with cold ethanol. The residue is dissolved in water and, while cooling in ice, is neutralised with dilute hydrochloric acid. The precipitated product is filtered off with suction, washed with water and dried. 19.5 g of 5-(4-methoxyphenyl)-4-methyl-2-(1H)-pyrimidinone are obtained. Melting point 210° C.

후처리

  1. temperatureThe mixture is heated at the reflux temperature for 8 hours
  2. filtrationthe reaction product is filtered off with suction
  3. washwashed with cold ethanol
  4. dissolutionThe residue is dissolved in water
  5. temperaturewhile cooling in ice
  6. filtrationThe precipitated product is filtered off with suction
  7. washwashed with water
  8. customdried

출처 및 근거

ORD 기록
ord-c13d2d9c19694666ab04d374bef008a8
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582834

반응 노트

불러오는 중…