Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,6-Nonanedione → 4-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,6-Nonanedione | HCID 26454 | — |
| 반응물 | 4-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester | HCID 178473358 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(5,7-Dipropyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-1-piperazinecarboxylic acid, ethyl ester | HCID 13686014 | 93.9% |
반응 단계
A mixture of 4.48 g (0.02 moles) of 4-(5-amino-4H-1,2,4-triazol-3-yl)-1-piperazinecarboxylic acid, ethyl ester, 3.12 g (0.02 moles) of 4,6-nonanedione and 50 ml of glacial acetic acid was refluxed for 12 hours. The resulting solution was evaporated to dryness in vacuo. The residue was partitioned and treated as described in Example 12 and gave 6.77 g of the desired product as colorless crystals, mp 130°-132° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04582833 |
| 출처 데이터셋 | uspto-grants-1986_04 |
| ORD ID | ord-be58f9a26e5748d680e52bd587380267 |
| 출처 메모 | uspto-grants-1986_04 |