Triethylamine → Ethyl (2-amino-2-methylpropyl)carbamate

HRID 1380588노트

반응식

HRID 1380588 반응식
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].C(N(CC)CC)C.Cl[C:15]([O:17][CH2:18][CH3:19])=[O:16]>CCOCC>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][C:15]([O:17][CH2:18][CH3:19])=[O:16]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 131282-Methylpropylenediamine

생성물 1

HCID 14722925Ethyl (2-amino-2-methylpropyl)carbamate수율 95%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
25 °C

실험 절차

To a mixture of 88.2 g (1 mol) of 1,2-diamino-2-methylpropane, 50 ml of triethylamine and 500 ml of diethyl ether was added dropwise to a solution of 27.1 g (0.25 mol) of ethyl chloroformate in 100 mL of ether. The reaction mixture was stirred for 16 hours at 25° C. and filtered. Evaporation of the filtrate to dryness gave 38 g (95%) of product which was identified by NMR and IR spectroscopy.

후처리

  1. filtrationfiltered
  2. customEvaporation of the filtrate to dryness

출처 및 근거

ORD 기록
ord-87b640d4f3644bb98cd3998ef6a7cc1b
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582855

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