Sodium Methoxide → 2-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

HRID 1380596

반응식

HRID 1380596 반응식
[CH3:1][O-:2].[Na+].Br[C:5]([CH3:17])([CH3:16])[C:6]([C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1)=[O:7]>CO>[CH3:16][C:5]1([CH3:17])[O:7][C:6]1([O:2][CH3:1])[C:8]1[CH:13]=[CH:12][C:11]([S:14][CH3:15])=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 114599841-Propanone, 2-bromo-2-methyl-1-[4-(methylthio)phenyl]-

생성물 1

HCID 201925252-Methoxy-3,3-dimethyl-2-(4-methylsulfanylphenyl)oxirane

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

95.1 g (1.76 mols) of sodium methylate are dissolved in 600 ml of methanol, and 437.1 g (1.60 mols) of 2-bromo-2-methyl-1-[4-(methylthio)-phenyl]-propan-1-one, dissolved in 300 ml of methanol, are added dropwise to this solution at reflux temperature. The methanol is then removed by distillation. The residue is poured into ice water, and the mixture is extracted with diethyl ether. The ether solution is washed with water, dried over Na2SO4 and concentrated. The crystals obtained are purified by vacuum distillation.

후처리

  1. additionare added dropwise to this solution
  2. temperatureat reflux temperature
  3. customThe methanol is then removed by distillation
  4. additionThe residue is poured into ice water
  5. extractionthe mixture is extracted with diethyl ether
  6. washThe ether solution is washed with water
  7. dry with materialdried over Na2SO4
  8. concentrationconcentrated
  9. customThe crystals obtained
  10. distillationare purified by vacuum distillation

출처 및 근거

ORD 기록
ord-623991528b314e8bad08a3849278be8e
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582862

연결된 노트

불러오는 중…