Morpholine → 2-Methyl-1-(4-(methylthio)phenyl)-2-morpholino-1-propanone

HRID 1380597

반응식

HRID 1380597 반응식
[CH3:1][C:2]1([CH3:15])O[C:3]1([O:13]C)[C:5]1[CH:10]=[CH:9][C:8]([S:11][CH3:12])=[CH:7][CH:6]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[CH3:15][C:2]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)([CH3:1])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11][CH3:12])=[CH:7][CH:6]=1)=[O:13]

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 201925252-Methoxy-3,3-dimethyl-2-[4-(methylsulfanyl)phenyl]oxirane

생성물 1

HCID 923872-Methyl-1-(4-(methylthio)phenyl)-2-morpholino-1-propanone

실험 절차

151.4 g (0.675 mol) of 3,3-dimethyl-2-methoxy-2-[4-(methylthio)-phenyl]-oxirane (melting point 62°-64° C.) are dissolved in 235.2 g (2.70 mols) of morpholine and the solution is warmed to reflux temperature.

후처리

  1. temperaturethe solution is warmed
  2. temperatureto reflux temperature

출처 및 근거

ORD 기록
ord-4ecf9a967c7d4b6baebe3047e916cac9
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582862

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