1-Propanone, 2-chloro-1-(4-chlorophenyl)-2-methyl- → 2-(4-Chlorophenyl)-3,3-dimethyl-2-methoxyoxirane

HRID 1380599노트

반응식

HRID 1380599 반응식
[CH3:1][O-:2].[Na+].Cl[C:5]([CH3:16])([CH3:15])[C:6]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)=[O:7]>CO>[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2([O:2][CH3:1])[C:5]([CH3:16])([CH3:15])[O:7]2)=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 5873561-Propanone, 2-chloro-1-(4-chlorophenyl)-2-methyl-HCID 10942334Sodium Methoxide

생성물 1

HCID 122808342-(4-Chlorophenyl)-3,3-dimethyl-2-methoxyoxirane

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

57.0 g (1.056 mols) of sodium methylate are dissolved in 360 ml of methanol, and 208.4 g (0.96 mol) of 2-chloro-1-(4-chlorophenyl)-2-methylpropan-1-one are added dropwise to this solution at reflux temperature. The methanol is then removed by distillation. The residue is poured into ice water and the mixture is extracted with diethyl ether. The ether solution is washed with water, dried over Na2SO4 and concentrated. The resulting oil is purified by vacuum distillation.

후처리

  1. temperatureat reflux temperature
  2. customThe methanol is then removed by distillation
  3. additionThe residue is poured into ice water
  4. extractionthe mixture is extracted with diethyl ether
  5. washThe ether solution is washed with water
  6. dry with materialdried over Na2SO4
  7. concentrationconcentrated
  8. distillationThe resulting oil is purified by vacuum distillation

출처 및 근거

ORD 기록
ord-5175ec569d2c4e839f19fd51131cb333
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582862

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