m-Chloroperbenzoic acid → 3-Chlorobenzoic Acid

HRID 1380605

반응식

HRID 1380605 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([O:10]O)=[O:9])[CH:3]=1.CC(N1CCOCC1)(C)C(C1C=CC(SC)=CC=1)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 923872-Methyl-1-(4-(methylthio)phenyl)-2-morpholino-1-propanone

생성물 1

HCID 4473-Chlorobenzoic Acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 13 g of m-chloroperbenzoic acid in 50 g of CH2Cl2 is added dropwise, at 0° and while stirring, to a solution of 20 g of 2-methyl-1-[4-(methylthio)phenyl]-2-morpholinopropan-1-one in 200 g of methylene chloride. Stirring is continued for a further 2 hours, in the course of which the m-chlorobenzoic acid formed is deposited in the form of a white precipitate. The reaction mixture is poured into ice/1N NaOH, and the organic phase is separated off, dried over Na2SO4 and evaporated on a rotary evaporator. The crude 2-methyl-1-[4-(methylsulfenyl)phenyl]-2-morpholinopropan-1-one which remains is recrystallised from ethyl acetate/hexane. Melting point 112°-113° C. (Compound No. 31).

출처 및 근거

ORD 기록
ord-0e4bb4809ec44e33b36b76361a0c9829
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582862

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