4,5-Diaminopyrimidine → 2-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

HRID 1380720

반응식

HRID 1380720 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16][C:17]1[C:22]([NH2:23])=[CH:21][N:20]=[CH:19][N:18]=1>>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[N:16]=[C:17]2[C:22]([NH:23][CH:19]=[N:18]2)=[CH:21][N:20]=1

참가 물질

3

반응물 2

HCID 837034,5-DiaminopyrimidineHCID 201845804-(Chlorosulfonyl)-2-methoxybenzoic acid

생성물 1

HCID 201845292-(2'-Methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride

실험 절차

Prepared analogously to Example C from 2.5 gm of 2-methoxy-4-chlorosulfonyl benzoic acid and 2.4 gm of 4,5-diamino-pyrimidine (crystalline product obtained from dihydorchloride and 1 mol of common salt) by refluxing for eight hours. The solid crude product was processed further without any purification.

후처리

  1. temperatureby refluxing for eight hours
  2. customThe solid crude product was processed further without any purification

출처 및 근거

ORD 기록
ord-6d842c7706d44ef9bc1746be111d8ca0
출처 데이터셋
uspto-grants-1986_04
특허 번호
US04582837

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